Transdermal Delivery of Aceclofenac: Effect of Piperine and Its Mechanism of Action

نویسندگان

  • KAPIL K. SHAH
  • MAHENDRA R. SHIRADKAR
  • HIMA BINDU
چکیده

Piperine, an amide alkaloid of black pepper, was investigated for transdermal enhancer activity using human cadaver skin in vitro with aceclofenac as the model drug. Furthermore, FT-IR studies were conducted to understand to possible enhancement mechanism. Piperine, at all three concentrations tested, significantly increased flux of the drug compared to control (p<0.05). Similarly permeability coefficient (Kp), cumulative amount release (Q24) and enhancement ratio (ER) shown significant increase over control sample whereas skin content of aceclofenac and lag-time of enhancer treated epidermal membrane shown proportionate reduction over control. FT-IR studies reveal that piperine reduces peak area by 19.17 % and 16.87 % for symmetric and asymmetric stretching peaks. In addition, piperine significantly reduces percentage of secondary structures of keratin at amide I band. These results indicate that piperine enhances transdermal permeation of aceclofenac by biphasic mechanism involving partial extraction of stratum corneum (SC) lipid and interaction with SC keratin.

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تاریخ انتشار 2011